Milan's success in Ibrahimovic's 222nd Serie A appearance made the veteran striker the fastest player to 150 wins in the Italian top flight in the three-points-for-a-win era - which started in 1994-95.
The 38-year-old made only his third appearance since arriving at San Siro for his second spell at the club, as two goals from Ante Rebic and one from Theo Hernández steered Milan to a third consecutive victory in all competitions.
Ibrahimovic broke Esteban Cambiasso’s record who had achieved the feat in 230 appearances. With two more games, Napoli captain Lorenzo Insigne is the next best player to reach the 150-match milestone.
Back for a second spell at the club after spending time at Paris Saint-Germain, Manchester United, and LA Galaxy, Ibrahimovic has helped Stefano Pioli's men climb up to seventh in Serie A. They are just two points behind Cagliari, who occupy the last Europa League spot.