Jurgen Klopp’s side have stormed ahead at the Premier League summit having stretched their unbeaten run in the top flight to 38 games, and United will no doubt be out to add another blemish on their record. Another three points for Liverpool would further showcase the chasm between the two teams while maintaining their 14 point lead ahead of Manchester City.
United head into the clash off the back of two consecutive wins and clean sheets in the FA Cup and Premier League respectively, and there's no doubt that Ole Gunnar Solskjaer will have a few tricks up his sleeve.
Here are the three things to look forward to as Liverpool host Manchester United at Anfield.
3. Returning Reds provide boost for Klopp
A number of returning faces could yet add another dimension and a much-needed boost to Liverpool's options, and propel them to greater heights. The Reds are set to be bolstered by the return of Fabinho and Joel Matip, with Dejan Lovren, Naby Keita, and James Milner not far away.
The returning players will probably start from the bench and will need some time to adjust after being sidelined for a long time, but their presence alone bolsters what is an already impressively strong outfit and alarmingly for the opposition, it only adds more strings to their bow.
2. Can Solskjaer's side spring a surprise?
United are the only team this season who have been able to hold Liverpool to a draw, and they came close to beating them back in October. The Red Devils have won just two of their last eight away games across all competitions, failing to even score in three of their last four, while they could lose three successive top-flight games on Merseyside for the first time since 1979.
However, the legendary Norwegian has managed to get a couple of big game results and the aim has to be to get all three points simply because of where they are in the table and how they can’t afford to lose. United are the only team in the Premier League with a better record against the top half than the bottom half. They've won five of the six games when they've had less possession (but only four of the 14 when they've had more).
1. The battle of the forwards
Sadio Mane, Mohamed Salah, and Roberto Firmino have combined for 38 goals so far this season, while United’s front three have netted a total of 39. Although, there are concerns over Marcus Rashford, who has provided 19 of the trio's 39, who could miss the game with a lower back injury.
Should Rashford fall short then he will undoubtedly be a big loss to the visitors as he has scored the opening goal in six Premier League games this season - a joint-league high heading into the weekend - while only Salah has scored more winning goals in the top flight this term. However, the Reds have had 16 different goal scorers in the league to date and a total of 19 across all competitions, while United have had just eight in the top flight.
3 things to look forward to as Liverpool host Manchester United at Anfield.