Messi is back in the Argentina squad for the first time since the 2019 Copa America, where Brazil beat Argentina 2-0 in the semi-finals.
The Blaugrana superstar should be ready to play during the friendly in Saudi Arabia, and Silva has chosen to look at the match as a challenge and relish it, rather than fearing what could happen.
"We are not concerned but proud to have a chance to face him," Silva told reporters on Monday, as per beIN Sports.
"[Argentina] have their star, we won't have ours [Neymar, who is injured], but Brazil is Brazil, and we showed it during our Copa America win.
"They are living a different moment, as are we when you consider the last few matches. Brazil versus Argentina is always a great game, with great football and scoring chances. There's a 50:50 winning chance for each side - let's hope we are more inspired then than they are."
Thiago Silva (Brazil) "We're proud to have a chance to face Messi. Argentina have their star, we won't have ours (Neymar), but Brazil is Brazil, and we showed it during our Copa América win."— FC Barcelona Fl ️ (@FCBarcelonaFl) November 11, 2019
Brazil winger Willian added, "He [Messi] is a great player, unmatched, the best in the world. We've faced Argentina when he played before, and this will be just like those times.
"There must be more attention on him, we must restrict his spaces. We'll not man-mark him, but whoever is around him must close down the spaces, not leave him room to think."
Argentina have worked hard under coach Lionel Scaloni to find an identity without Lionel Messi and they would be very keen to have their talisman back. They would want to start preparing for Copa America 2020, which will be their last big tournament before the 2022 World Cup.