Pogba had been fouled by Connor Coady in the box, prompting referee Jonathan Moss to point to the spot and while it was Rashford who took the penalty last week during their win over Chelsea, instead it was the Frenchman who strode to take the spot-kick.
The duo were seen being involved in a conversation before the penalty, with it being eventually saved by Wolves goalkeeper, Rui Patricio, which cost the Red Devils from getting all three points on the night.
"Paul wanted to take it, it's that simple. Anyone can miss a penalty, he has scored so many penalties and it is normal to miss one. It is simple, if you want to take it, you take it. I took one last week so for me it's no problem that he took it," Rashford said to Mirror, post the game.
"It's unfortunate he didn't score but that's football. The confidence that you're going to score is always the same. We practice all week and we score the majority of them."
The decision though did not go down too well with United legend, Gary Neville who cited a lack of leadership in the club's ranks as the reason behind Pogba taking the penalty.