The hosts have won all four of their games under interim manager Ole Gunnar Solskjaer and will hope for a comfortable fixture against the struggling Championship outfit. On paper, there seems to be only one winner tonight, but cup competitions have a knack for springing up surprises.
Here are three things to look out for as the Red Devils host the Royals -
3. Reading's Poor Run
Jose Gomes took charge of the club only two days before Christmas following the departure of Paul Clement, and is yet to figure out his best eleven. Clement oversaw a dreadful start to the Championship season, and left the team in tatters. Now, it's up to Gomes to turn the corner.
So far, the managerial switch hasn't done Reading any favours, as they are still searching for their first win under the Portuguese after three rounds of fixtures. Getting a goal at Old Trafford will be their main objective, which might help break the monotony of this lopsided encounter.
2. Chances for Lukaku and Sanchez
Romelu Lukaku and Alexis Sanchez both endured a frustrating last few months under Jose Mourinho. Now under Ole Gunnar Solskjaer, things are finally looking up for the superstar duo. Both were allowed to stretch their legs in Wednesday's 2-0 win at Newcastle and are expected to play a more prominent role against Reading on Saturday.
Since taking charge, Solskjaer has diligently focused on his attack-minded players and has worked on getting the best out of them. The duo have the ability to turn a tie on their own and a good performance today could give their confidence a much-needed boost.
1. Solskjaer's Bid for a Permanent Position Continues
As per reports, Manchester United are still not entirely convinced by Solskjaer's abilities to give him the role long-term and are working to lure Mauricio Pochettino from Tottenham Hotspur.
From the club's viewpoint, this move makes perfect sense as the Argentinian is most certainly the more qualified of the two. But the Norwegian has chosen to remain hopeful, and will try his best to convince the board.
The quality of football has been top-notch since his appointment, but they are yet to face a proven opponent. Reading too shouldn't be much of a challenge but another win - his fifth on the trot - would probably help his case.
Previewing the FA Cup fixture between Manchester United and Reading